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N Engl J Med 384(11):989–1002 [DOI] [PubMed] [Google Scholar] 24.Horn DB, Kahan S, Batterham RL et al Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials

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Conservative titration (6 to 8 week holds) For people who are GI-sensitive, have a history of poor tolerance to GLP-1 medications, or simply prefer to minimize side effects at the cost of slower initial results