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Reduces intestinal glucose absorption and reshapes the gut microbiome Improves insulin sensitivity in muscle and fat Modulates inflammation, autophagy, and mTOR — the same pathways targeted by geroscience ORGAN-SPECIFIC EFFECTS (beyond glucose) Cardiovascular: AMPK-dependent and -independent cardioprotection Oncology: pro-apoptotic, anti-proliferative signals across multiple cancer models Renal/hepatic: protective at therapeutic doses, harmful when accumulated MECHANISTIC SPECULATION vs

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Several GLP-1 and dual GIP/GLP-1 receptor agonists have been developed to harness these pharmacological effects in the treatment of type 2 diabetes, with some demonstrating robust effectiveness in weight management and prevention of cardiovascular diseases