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Low indicates evidence derived from sources that cannot establish causality, such as pharmacovigilance databases, case series, or preliminary/conflicting retrospective analyses Discussion While GLP-1RAs hold considerable promise for ophthalmic disorders, particularly DR and glaucoma, significant hurdles remain in translating preclinical findings into routine clinical practice
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83 , 84 Collectively, these findings indicate that incretin signalling modulates the metabolic‐inflammatory interface of the brain, restoring homeostatic equilibrium under insulin‐resistant or neuroinflammatory conditions
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