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GLP1 medications have led to increased risk of medullary thyroid cancer in rodents and therefore should not be used in those with a personal or family history of medullary thyroid cancer or MEN2 ...
Further study has indicated that EC and haematopoietic lineage (HL) cell GLP-1Rs are not critical for the antiatherogenic effects of GLP-1RAs, but Tie2-targeted GLP-1R + cells are critical for the anti-inflammatory action of semaglutide in the liver [161]
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