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The complexity of lipidated peptide impurity profiles, as the January 2026 Analytical Scientist review documented, requires orthogonal analytical methods capable of separating and characterising species that differ by a single amino acid residue or by the presence or absence of a single linker modification
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A prominent trial includes the SURPASS-2 study , where Tirzepatide demonstrated superior efficacy over Semaglutide in a 40-week phase 3 trial
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