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In the STEP 1 trial, of the average 13.6 kg weight reduction, 8.3 kg (62 %) was fat mass and 5.3 kg (38 %) was lean body mass (including muscle and other non-fat tissues) [14]

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Similarly, some authors observed that metformin users had a lower clinical severity of TC at presentation and a longer disease free survival in metastatic patients ( Interesting findings emerged also from studies in vitro on different types of thyroid cells (human anaplastic, differentiated cancer cells, as well as human normal and cancer thyroid primary cell cultures, TC stem cells and rat follicular thyroid cells)