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Table 8 indicates Mpro substitutions and combinations of Mpro substitutions that have been found to reduce nirmatrelvir activity ≥3-fold (based on IC50 or Ki values) in biochemical assays using recombinant SARS-CoV-2 Mpro
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Why it’s unique: Renuvion is currently the only FDA-cleared device for subcutaneous skin tightening, making it the most advanced option in non-excisional contouring
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