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Conversely, genera such as Erysipelatoclostridium , Bacteroides , and Lachnoclostridium were elevated in the db/db group but notably reduced after treatment, suggesting that Tirzepatide may improve metabolic function by modulating the microbiota (Figures 7B–E)

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HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase