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Semaglutide (weekly injectable) Dosing frequency: Once weekly, same day each week Half-life: approximately 7 days (165 to 184 hours) Peak concentration: 1 to 3 days after injection Recommended timing approach: Most flexible of all GLP-1 formulations due to the long half-life

Digestive Enzymes

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The primary mechanism of action of the SGLT2i is to inhibit glucose reabsorption in the proximal tubule leading to glucosuria which is in the range of 60–80 grams per day (19,20)