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A 2019 study identified potential cases of severe pruritus (itching) related to cetirizine withdrawal dating back to at least 2008, for instance, while a 2016 study reported similar cases in the Netherlands tied to levocetirizine
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Activation of these receptors modulates mesocorticolimbic neurotransmission through dopaminergic, GABAergic, and glutamatergic pathways, which are critically involved in addictive behaviors
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