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The increase in energy expenditure could be explained by enhanced levels of PPAR-α, PGC-1, and uncoupling protein-1 (UCP-1) in BAT as well as elevated levels of proopiomelanocortin in the hypothalamus
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The most common side effects (incidence ≥ 5%) may include: nausea, diarrhea, vomiting, constipation, stomach-area pain, headache, tiredness (fatigue), heartburn, dizziness, feeling bloated, belching, low blood sugar in patients with type 2 diabetes, gas, stomach infection (gastroenteritis), acid reflux disease, and common cold symptoms
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