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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Machida A., Suzuki K., Nakayama T., Miyagi S., Maekawa Y., Murakami R., Uematsu M., Kitaoka T., Oishi A

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In most studies, a study population with pre-existing cardiovascular disease is chosen in order to aim at a higher event rate in a shorter study duration (54–61)