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Figure 2 2.3 Clinical implications The triple-hit paradigm shifts the understanding of PDM from an autoimmune and insulin resistant process to one that is fibro-inflammatory, malabsorptive, and bihormonal deficient ( 2.4 Pathophysiologic endotypes of PDM The relationships between Chronic Pancreatitis, Pancreatic Ductal Adenocarcinoma, Cystic Fibrosis, and pancreatectomy are centered on pancreatogenic diabetes, yet these conditions have different driving mechanisms behind dysglycaemia
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