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By exploiting their ability to react with both cysteine and lysine via distinct mechanisms, these reagents enable the formation of bioconjugates with superior chemoselectivity and stability compared to conventional maleimide–thiol conjugates

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However, significant limitations exist in the current evidence: Most human data comes from small studies, with limited randomised controlled trials specifically designed to assess alcohol consumption The mechanisms by which GLP-1 medications might reduce alcohol intake are not fully understood Individual responses vary considerably, and not all patients experience changes in drinking behaviour Long-term effects and safety of using these medications specifically for alcohol reduction remain unknown The MHRA has not approved GLP-1 receptor agonists for alcohol use disorder, and these medications should not be considered a treatment for problematic drinking