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Fifth, while TriNetX spans multiple healthcare organizations, its data primarily derive from U.S

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Conclusion • Dietary modification personalized to individual preferences and treatment goals (e.g., caloric deficits of ∼500 kcal/day), combined with structured physical activity (e.g., ≥150 minutes of moderate-to-vigorous exercise per week), produces additive benefits beyond GLP-1 therapy alone, enhancing weight loss, improving body composition, and reducing visceral fat and inflammation