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The NHS recommends the following steps: Sit down and lean forward slightly (do not tilt your head back, as this can cause blood to run down the throat) Pinch the soft part of your nose (just above the nostrils) firmly for at least 10–15 minutes without releasing pressure Breathe through your mouth and avoid speaking, swallowing, or sniffing Apply a cold compress to the bridge of your nose, which may help constrict blood vessels Once bleeding has stopped, avoid blowing your nose, bending down, or strenuous activity for 24 hours Avoid hot drinks and alcohol for 24 hours after a nose bleed Preventative measures can reduce the frequency of nose bleeds, particularly if environmental factors or nasal dryness are contributing: Use a humidifier in your home, especially during winter months, to maintain moisture in the air Apply a thin layer of petroleum jelly or saline nasal gel inside the nostrils to keep the nasal mucosa moist Avoid picking or rubbing your nose , and blow your nose gently when necessary Stay well hydrated to maintain mucosal moisture Discuss your medications with your GP, particularly if you take anticoagulants, antiplatelets, or nasal sprays If nose bleeds persist despite these measures , your GP may refer you to an ear, nose, and throat (ENT) specialist for further assessment

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Ongoing research and development strategies focus on enhancing efficacy and convenience, such as developing dual and triple receptor agonists and new formulations for oral administration or extended dosing schedules