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Pharmacokinetics and Metabolic Stability in Animal Models After sc dosing in rats (0.1โ1.0 mg/kg) and cynomolgus monkeys (0.03โ0.3 mg/kg), peak plasma concentrations were reached within 8โ12 h and modulated food preference, reduced food intake, and caused weight loss without decreasing energy expenditure [41,42,43]
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GLP-1 treatments mimic a natural hormone that regulates appetite, digestion, and insulin levels