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Adipose tissue failure forces the spillover of excessive free fatty acids (FFA) into the systemic circulation, causing ectopic fat deposition in non-adipose organs, including the skeletal muscle and, critically, the liver (Stefan et al., 2025

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10.1530/eje.0.1460863 [DOI] [PubMed] 24.Fadini GP, Bottigliengo D, D’Angelo F, Cavalot F, Bossi AC, Zatti G, Baldi I, Avogaro A