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In rodents, SG does not increase alcohol consumption [273,274,275] (for a detailed review, see also [276])
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Specifically, mutagenesis of ECD, ECL1 and ECL3 individually increased the basal activity of GCGR, which could result from the interruption of intramolecular interactions between the ECD and ECL1/3 that otherwise stabilize the receptor in an inactive state
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