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BOL Blood Oxygen Level-dependent, MDR-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease, MMSE Mini-Mental State Examination, MoCA Montreal Cognitive Assessment, NA not available, NMSS National Multiple Sclerosis Society, PHQ-9 Patient Health Questionnaire, PDQ-39 Parkinson’s Disease Questionnaire, PI principal investigator, SR sustained release, SMA Supplementary Motor Area a The recruitment status as found in the registration protocol of the trials b The actual enrollment (not the estimated enrollment) as found in the registration protocol of the trials Risk of bias in included studies We used the RoB 2 tool to assess the risk of bias for each of the included studies