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Stop the drug, and you get rebound sympathetic activation, typically within 4 to 6 hours of last use, substantially earlier than opioid withdrawal
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There are some non-M1 and non-M2 “restorative” type macrophages, which have both anti-inflammation and anti-fibrogenic features, highly express matrix metalloproteinase (MMP), and have a LY6C low , F4/80 + phenotype (Kazankov et al., 2019)
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