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Numerous clinical trials and real-world studies have demonstrated the effects of both medications, not only on weight loss but also on other key health biomarkers, such as blood glucose levels

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Event Phase 2 Rate (12 mg group) Phase 2 Rate (Placebo) Nausea 45.8% 11.6% Diarrhea 33.3% 9.3% Vomiting 22.2% 2.3% Constipation 16.7% 7.0% Decreased appetite 22.2% 2.3% The nausea incidence at the highest dose — a nausea percentage of roughly 46% — makes it the single most reported adverse event in retatrutide clinical trials 2026 data