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Type-2 diabetes mellitus (T2DM), which accounts for approximately 90% to 95% of all diagnosed diabetes, is a progressive disease resulting from an insulin secretory defect characterized by insulin resistance and some degree of insulin deficiency
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[57] Central nervous system and appetite regulation [edit] Semaglutide crosses the blood-brain barrier to interact with the arcuate nucleus of the hypothalamus, a crucial brain region for energy balance
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