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If the solution becomes cloudy, develops particles, changes color, or develops an unusual smell at any point during the 28-day usage window, discard it immediately
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By analyzing peptide-binding modes of endogenous ligands (GLP-1 and glucagon) and GLP-1R/GCGR dual agonists (peptide 15, oxyntomodulin, SAR425899 and MEDI0382), detrimental and beneficial effects on peptide recognition caused by amino acid variations were unmasked at the residue level, offering mechanistic explanation of their differentiated agonist potencies
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