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It helps regulate: Satiety (feeling full) Insulin secretion Gastric emptying The blood-sugar response after eating How the body partitions energy This is why the idea that “the microbiome controls appetite” is better described as microbiome-influenced appetite signaling, where microbial metabolites may help shape satiety, gastric emptying, and the metabolic response

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Deciphering metabolic messages from the gut drives therapeutic innovation: the 2014 banting lecture