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It may be used as monotherapy or combined with oral agents
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At week 52, mean AHI change was -25.3 events per hour with tirzepatide versus -5.3 with placebo in the first trial, and -29.3 versus -5.5 in the second, from mean baselines of 51.5 and 49.5 events per hour (Malhotra et al., New England Journal of Medicine, 2024)
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