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The STEP trials showed average weight loss of 1.5 to 2% weekly during weeks 4 to 20, which is faster than the 0.5 to 1% weekly rate associated with maximal fat-to-muscle loss ratio
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For example, the schedule could progress to 2 mg, then to 4 mg, 6 mg, 8 mg, 10 mg, and potentially 12 mg per week
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