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This finding suggests a more dysfunctional reward system, potentially conferring greater vulnerability to AUD.158 Conversely, a clinical trial investigating intravenous or intragastric alcohol administration reported no significant alterations in plasma GLP-1 concentrations in healthy male volunteers.159 The modulatory effects of GLP-1RAs on cocaine addiction-related behaviors have also been well-documented.160 Systemic administration of exenatide has been shown to suppresses conditioned place preference in cocaine-exposed mice