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Caloric restriction during weight loss can temporarily affect thyroid hormone levels , which may contribute to cold sensitivity without representing true hypothyroidism
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The trial anchors are STEP for semaglutide ( NEJM , 2021), SURMOUNT for tirzepatide ( NEJM , 2022), and SURMOUNT-OSA for tirzepatide in sleep apnea ( NEJM , 2024)
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