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In patients with T2DM, adherence to GLP-1 RAs therapy is often suboptimal, although it tends to be higher among those receiving once-weekly formulations (57)
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Consistent with these data, central administration of the GLP-1R agonists liraglutide and exendin-4 increases energy expenditure and BAT thermogenesis through mechanisms that include AMPK signaling in the mediobasal hypothalamus [666]
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