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9.2 Atrial fibrillation, stroke and arrhythmia biology Stroke reduction has been a recurring signal in several GLP-1 RA analyses, particularly with semaglutide in SUSTAIN-6 and favourable stroke trends across pooled datasets (2, 5)

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In clinical trials, semaglutide and tirzepatide consistently lower C-reactive protein (CRP), yet only 20–60% of that improvement can be explained by weight or glucose changes