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For most patients, the first-use rule is the binding constraint because you're injecting weekly and the pen is designed for single-patient, multi-dose use over four weeks

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Further investigations are needed to establish whether the lower risk of adverse clinical events that we observed amongst patients treated with GLP-1 receptor agonists and/or DPP-4 inhibitors compared with treatment with other antidiabetic therapies is due to a reduced intestinal and systemic inflammation

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