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Taken together, irrespective of sequence, step-up or step-down strategies should be guided by the patient’s observed trajectory, including percentage weight change, tolerability, and the risk profile of obesity-related complications, given heterogeneity in fiber responses and variable persistence with GLP-1RA therapy in routine practice

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Conclusion Taking spironolactone and Ozempic® together is a common practice, particularly for individuals managing the multifaceted symptoms of PCOS or hormonal imbalances