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In yeast assays, oxyntomodulin showed enhanced coupling to Gα i compared to GLP‐1 (Weston et al., 2014) which, given the possible dependence of oxyntomodulin‐induced ERK/1/2 phosphorylation on Gα i (Wootten et al., 2016), could be relevant to the relative preference of this peptide for ERK1/2 signalling
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