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Investigation of nausea is challenging in mice due to the lack of an emesis response but can be performed using conditioned taste aversion or behavioural assays (Jones, Bloom, et al., 2018) or in other rodent species such as shrews (Borner et al., 2020)

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Within the tirzepatide treatment arm, the study’s most common adverse effect, gastrointestinal disorders, occurred in 46.0% of patients who experienced a cardiorenal end point versus 41.4% of patients who did not