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It normalized markers such as malondialdehyde, nitric oxide, IL-6, and specific matrix metalloproteinases while increasing superoxide dismutase and IL-10 in the affected nerves [103]
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These factors include increased accumulation of advanced glycation end products (AGEs), chronic inflammation due to increased proinflammatory cytokines, and bone microvascular lesions with decreased vascular flow and increased bone fragility
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