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Notably, while there exists three distinct Epac2 isoforms, e.g., Epac2A, Epac2B and Epac2C, only Epac2A is presented in pancreatic islet and exhibits functional roles in β-cells (Song et al., 2011), imply that Epac2A is predominant downstream effector when cAMP triggers the PKA-independent signaling in pancreatic β-cells
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