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The New Era of Weight Loss. How GLP-1, GIP, and Glucagon-Based… | by 🧬Peter Marino, M.S. CHC CPT🧬 | ILLUMINATION Scholar | Medium

Glp1r SAN−/− and Gcgr SAN−/− mice and controls (wild type, Cre, floxed) were produced by breeding Hcn4-Cre hemizygous mice with floxed Glp1r mice [18]or floxed Gcgr mice [19], respectively

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Trulicity works by: Stimulating glucose-dependent insulin secretion from pancreatic beta cells when blood glucose levels are elevated Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose output Slowing gastric emptying , which moderates the rate at which glucose enters the bloodstream after meals Reducing appetite and food intake through central nervous system effects, often leading to weight loss The key advantage of this dual approach is that Basaglar addresses basal insulin deficiency , whilst Trulicity enhances the body's meal-related insulin response and provides additional metabolic benefits