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In 1992, exendin-4, which can stimulate insulin secretion, was isolated from Heloderma suspectum venom with 53% homology to mammalian GLP-1, and can resist DPP-4 degradation and has low renal clearance rate (Muttenthaler et al., 2021)
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For some patients, the advantages of improved glycemic control and weight reduction may outweigh the inconvenience of managing yeast infections
