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Phase 2 trial results, published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023), demonstrated that participants receiving the highest dose of retatrutide lost an average of approximately 24% of their body weight over 48 weeks — a finding that attracted considerable attention from the medical and scientific communities
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These findings represent substantial improvements over traditional anti-obesity medications and approach the efficacy levels historically associated with bariatric surgery
