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A Review in Nature Reviews Endocrinology discusses why patients discontinue GLP-1 receptor agonists and tirzepatide, the metabolic and cardiovascular effects of this discontinuation, and the need for additional research on how to
[DOI] [PubMed] [Google Scholar] 27.Pratley R., Amod A., Hoff S.T., Kadowaki T., Lingvay I., Nauck M., Pedersen K.B., Saugstrup T., Meier J.J., PIONEER 4 investigators Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): A randomised, double-blind, phase 3a trial
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For the study, WashU Medicine researchers analyzed de-identified medical records in a database maintained by the US Department of Veterans Affairs
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