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In contrast, the FREEDOM trial reported that the constant infusion of exenatide (20 ug daily for 3 months followed by 60 µg daily) through an osmotic minipump was non-inferior to the placebo in 4156 T2DM patients (with a median follow-up of 16 months) (Ruff et al
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The mechanism is overlapping with what I covered in the ADHD post earlier this year: estrogen’s role in dopamine signalling means that estrogen withdrawal, in the premenstrual window, postpartum, and most significantly through perimenopause, can strip away the neurochemical scaffolding that was keeping symptoms manageable
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