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FDA Approves Oral Semaglutide as the First Oral GLP-1 Pill?

Early results from a small clinical trial look promising and they plan to begin a larger clinical trial later this year of GLP-1 drugs to treat opioid addiction in the outpatient setting

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They tried a few tricks: DPP-4-resistant versions: tweaking the GLP-1 molecule so DPP-4 can’t “see” where to cut it Fatty acid tails: causing the GLP-1 to latch onto albumin in your blood, hiding from DPP-4 Encapsulation: wrapping the molecule in protective coatings so it survives longer before being exposed to enzymes These hacks meant the drug could hang out in the bloodstream for hours, or even days, instead of minutes