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In the past, researchers had to terminate studies on other drugs similar to orforglipron because of this effect
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Adjunctive basal GLP-1-RA therapy in patients after MBS may be a promising treatment choice in weight management in addition to lifestyle changes, not only due to increased GLP-1 signaling, but also to a putative blunting effect on metabolic adaptation that occurs after MBS, increased fat oxidation, and decreased carbohydrate and protein oxidation
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