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[ 24 ] The HBP is responsive to the availability of nutrients and energy status and is critical for the production of UDPโNโacetylglucosamine (UDPโGlcNAc), [ 25 , 26 ] which is essential for the postโtranslational modification OโGlcNAcylation of proteins
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Moreover, GLP-1 RAs may promote a shift in macrophage polarization from the M2 to the M1 phenotype, thereby restoring antitumour immune responses and enhancing the potential efficacy of immune checkpoint blockade, an area of growing interest in both CRC and PDAC, where response rates to immunotherapy remain modest
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