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However, patients currently on weekly GLP-1 medications should remain aware of the following side effects that may improve — or in some cases intensify — with dose or frequency changes: Nausea, vomiting, or diarrhea — most common during dose increases Constipation — particularly at higher doses Injection-site reactions (redness, bruising, lumps) — manageable with rotating injection sites Fatigue during dose escalation Do not change your GLP-1 dose, injection frequency, or brand without speaking with your prescribing provider first

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This delayed gastric transit is one reason these medications reduce appetite and increase feelings of fullness