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Food and Drug Administration’s Mini-Sentinel study using ICD-9-CM coding (5), which had a PPV of 63% but no estimate of sensitivity, and adapted this algorithm to accommodate the change to ICD-10-CM coding
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Signs of impaired intestinal[146] pro-glucagon processing have been described in probands with PC1/3 deficiency and may contribute to the development of the obesity phenotype secondary to reduced GLP-1 synthesis
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