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Table 8: Glycemic Parameters at Week 24 in a Placebo-Controlled Trial of Saxagliptin Coadministration with Metformin HCl in Treatment-Naive Patients* Add-On Combination Therapy with Metformin HCl versus Glipizide Add-On Combination Therapy with Metformin HCl

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Tirzepatide 15 mg (the highest available dose) was the most effective in lowering A1c versus placebo (mean difference [MD], −2%, 95% CI -2.16 to -1.84), followed by tirzepatide 10 mg (MD -1.86%, 95% CI -2.02 to -1.84) and semaglutide 2 mg (MD, 95% CI -1.62%, -1.96 to -1.28)