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One 2026 narrative review concluded that GLP-1 receptor agonist therapy is associated with meaningful nutritional deficiencies and that individualized nutritional assessment and lab evaluation may be appropriate, especially in people at higher risk of malnutrition

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For comorbid obesity, tirzepatide (Mounjaro/Zepbound) shows higher mean weight loss than semaglutide in head-to-head data (SURMOUNT-5, 2024)