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For subjects treated with the highest dose of tirzepatide (15 mg per week), the risk to develop any major adverse cardiovascular event (MACE-4 composed of myocardial infarction, stroke, hospitalization for angina, and all-cause death) was estimated at 0·50 (0·26–0·95)
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Regular physical activity : Successful weight maintainers typically engage in high levels of physical activity—at least 200-300 minutes per week of moderate-intensity exercise (equivalent to 40-60 minutes 5 days weekly), plus resistance training
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